Bracket’s Presentations at the Upcoming ISCTM and ECNP Conferences in Amsterdam

International Society for CNS Clinical Trials and Methodology (ISCTM) Autumn Meeting

Formal poster session held on Friday, 28 August 2015, 17:00 – 18:30

Is a Computer Simulated Rater Good Enough to Administer the Hamilton Depression Rating Scale in Clinical Trials? — Sachs G, DeBonis D, Wang X, Epstein B 

Are Hamilton depression rating Scale scores obtained by a computer simulated rater within the range expected from site-based raters? Concern about the high rate of failed clinical trials fuels the desire for better measurement techniques.

Identical Ratings Are An Early Marker of Data Quality Issues — Kott A and Daniel DG

Whether there is an association between the presence of identical PANSS ratings between screening and baseline and the presence of identical PANSS ratings after randomization.

A Methodology for Evaluating Clinical Trial Sites and Raters Based on Performance Data — Miller D, Feaster T, Allen S, Gratkowski  H, and Butler A

Is it possible to use past training, certification, and clinical outcome ratings data to improve clinical trial site and rater selection?

The Interview for Clinician-Rated Dimensions of Psychosis Severity (IPS) — David DG, Velligan D, Fu DJ, Brown B, and Alphs L

Rationale for creation of a semi-structured interview and manual to facilitate accurate and reliable use of the CRDPSS.

28th European College of Neuropsychopharmacology (ECNP) Congress

Amsterdam, Netherlands
August 29 – September 1, 2015

Effects of PANSS Audio/Video Recordings on the Presence of Identical Scorings Across Visits — Kott A and Daniel DG

Identical scorings (all PANSS items rated exactly the same across consecutive visits within a single subject) are relatively common and affect on average 4-5% of study data (Kott and Daniel, 2014; Daniel and Kott, 2014). Audio/Video recording is believed to improve data quality through various mechanisms including Hawthorne effect (improvement of raters’ behavior in response to their awareness of being observed). Dr. Daniel and Dr. Kott examined whether audio/video recording of the PANSS interview is associated with a decrease in percentage of PANSS identical scorings in the data.

The above poster will be presented on Monday, 31 August from 12:15 – 13:45

Regional Variation in Data Analytic Findings in Global Schizophrenia Clinical Trials. — Daniel DG and Kott A

Dr Daniel and Dr Kott have previously demonstrated that error rates in rating the PANSS and CGI in clinical trials may be reduced in association with monitoring and intervention (Daniel, Busner, McNamara, 2010). They hypothesized that cultural variation in perceptions of  the severity and importance of schizophrenic symptoms are most globally would lead to geographic differences in error rates utilizing the CGI and PANSS.

The above poster will be presented on Tuesday, 1 September from 12:15 – 13:45