Randomization is a core component in the design and implementation of RTSM in clinical trials. Two of the most important elements to the integrity of a controlled clinical study are the patient randomization and the treatment blinding, and the RTSM system is the backbone supporting these controls. In the February issue of Applied Clinical Trials, Bracket’s Dr. Scott Hamilton contributes to an article describing the results of a simulation study comparing a novel randomization procedure with a more traditional procedure. In this case, the authors compared two forms of utilizing block pattern distribution, which can minimize selection bias in a randomization scheme.
Bracket developed Precision Block Design™ for sponsors who want or need to utilize block pattern distribution in their randomization lists when using Bracket RTSM™. The use of Precision Block Design™ does not add additional time nor cost to the creation of the randomization list. For more information about selection bias and/or Precision Block Design™ you can download our brief whitepaper on the topic here, or contact Bracket for more details.
FULL CITATION: A Comparasion of Techniques for Creating Permuted Blocked Randomization Lists.Applied Clinical Trials. 2016 Feb 12.
JOURNAL: Applied Clinical Trials
AUTHORS: Carol Shum, Scott Hamilton, PhD, Kim Hung Lo