Why Bracket?

Science. Technology. Service.

Bracket offers a unique suite of solutions, with a unique perspective on clinical research development. We focus on bringing together best-in-class science, technology and service to drive superior clinical outcome results for our clients and for their patients.

Increasing the Power of Clinical Research Data.

Who We Are

Bracket was created in 2011 through the merger of the Specialty Clinical Services and Clinical Technologies Group business units within United BioSource Corporation (UBC). Bracket is no longer owned by UBC and is an independent business.

Bracket, with nine offices and more than 700 employees worldwide, is a clinical trial technology and specialty services provider dedicated to helping biopharmaceutical sponsors and contract research organizations increase the power of their clinical research data by leveraging core competencies in Science, Technology, and Service.

Leadership Team

Being a Leader Requires Experience, Knowledge, and Integrity

Mike Nolte CEO

Mike joined Bracket in the first quarter of 2018 as the Chief Executive Officer. Mike is a seasoned operational leader whose career spans the healthcare, technology and financial services industries.

Mike joins Bracket after recently serving as Chief Executive Officer at Influence Health. Prior to that position, Mike served as President, Chief Operating Officer and Director of the public company MedAssets (MDAS), prior to which he spent 7 years at General Electric (GE), including roles as Vice President and General Manager of Americas Services for GE’s Healthcare IT business, where he led more than 1,700 teammates focused on GE’s $900 million healthcare software portfolio, VP and GM of GE’s $230 million enterprise revenue cycle software business and VP and GM of marketing and product management for GE Healthcare IT’s ambulatory segment.
He also spent five years with McKinsey & Company and started his career as a U.S. Army Officer, finishing up as a Captain and Company Commander for an airborne, rapid deployment, medical supply chain and maintenance organization.

Mike holds a Master of Business Administration degree from The University of Chicago Booth School of Business and a Bachelor’s Degree from the University of Notre Dame.

Sam Whitaker Chief Technology Officer

Sam is responsible for global product strategy, product innovation and technology development.  Prior to joining Bracket, Sam was a founder of Greenphire, a global clinical technology company that was the first to bring payment technology into the clinical environment. During his 9-year tenure at Greenphire, Sam was responsible for creating Greenphire’s payments technology platform and its commercially available products, successfully bringing those products to market and scaling the business to support over 500 customers globally. Sam graduated from the University of Pennsylvania.

Christopher L. Crucitti Chief Commercial Officer

Christopher L. Crucitti, MS, has joined Bracket as Chief Commercial Officer and will be leading the commercial functions of the organization, as well as the go-to-market strategy, to drive the continued growth of Bracket’s already market-leading clinical technology solutions platform.

Crucitti brings significant experience and expertise in the clinical and R&D domains.   He has led organizations to significant revenue and profitability growth, while maintaining a high level of customer service and quality delivery.  He joins Bracket from Science Exchange, having served as Chief Commercial Officer for the world’s largest enterprise platform to manage outsourced R&D services.  Prior to Science Exchange, he held various senior executive-level positions and oversight of commercial functions within the CRO industry (most notably Worldwide Clinical Trials and inVentiv Health Clinical) overseeing solutions spanning technology, consulting, strategic resourcing, clinical development and R&D.

Mitchell Blumenfeld Chief Financial Officer

Mitch joined Bracket in May 2018 and is responsible for the accounting and finance functions.  He joins Bracket from PCI Pharma Services, the world’s largest provider of outsourced pharmaceutical packaging and related services where he was responsible for all financial management for 18 facilities across North America, Europe and Australia.  He led PCI’s finance functions during a period of rapid growth, including a ten-fold increase in EBITDA and the successful completion of 5 acquisitions in the US, UK, Ireland and Australia.

Prior to his time with PCI, Mitch worked for AmerisourceBergen as the Senior Vice President and CFO of the Drug Corporation and led the integration and finance functions for World Courier, the world leader in global cold chain and clinical trial logistics with offices in over 140 countries.  Mitch started work with GE, having a career spanning 15 years and roles in the US and Europe with the Appliances, Lighting, Information Services and Water Technology businesses as well as 5 years in the Corporate Audit Staff.  He is a graduate of GE’s Edison Engineering Program and Advanced Courses in Engineering.

Mitch holds a B.S. in Computer Science Engineering from Bucknell University and a M.S. in Computer Science & Applications from Virginia Tech.

David G. Daniel, MD Sr. Vice President and Chief Medical Officer

Clinical Professor of Psychiatry, George Washington University

Dr. Daniel provides overall scientific, clinical and strategic direction for Bracket’s services.

Dr. Daniel was the founder and President of Global Learning, LLC which was acquired by United BioSource Corporation in July 2006. He formerly served as Medical Director of the NIMH Neuroscience Center at Saint Elizabeth’s, Director of Clinical Trials for the Stanley Foundation, and was a founding Principal of Best Practice, LLC.

For over 20 years, Dr. Daniel has supervised and trained raters in psychiatric clinical trials in the US and globally. He has published numerous scientific articles involving clinical trials and investigations of the psychopathology of mental illness. He has received patent protection for new treatment approaches in epilepsy, anxiety disorders and psychotic disorders.

Dr. Daniel graduated Phi Beta Kappa and Magna Cum Laude from Emory University and obtained his medical school and psychiatry post-graduate training at Vanderbilt University, where he served as chief resident. He was a medical staff fellow and senior staff fellow within the intramural program of the National Institute of Mental Health (DIRP, NIMH) for five years.

James Jay Senior Vice President, Endpoint Solutions

James Jay is Senior Vice President, Endpoint Solutions. He has 18 years of experience building successful software solutions for healthcare and life sciences. For the last six years he led the Global Imaging IT business at Agfa HealthCare, where he transformed the business strategy while creating a new market segment and established early market leadership. Prior to Agfa, James spent 13 years at GE, where he led the Global Cardiology IT business and held other roles across R&D and program management.

James has an MBA in Global Management from American Intercontinental University and a BS in Computer Science from the University of Oregon.

Jim Primerano Sr. Vice President and General Manager, eClinical

Jim leads the eClinical division of Bracket.  As Sr. Vice President and General Manager, he oversees all aspects of the eClinical solutions portfolio. With 15 years of clinical research and technology experience, he and his team bring innovative solutions to advance clients’ clinical objectives.  Prior to joining Bracket, Jim was Sr. Director of Product Strategy with Medidata Solutions, where he was responsible for market analysis to drive portfolio expansion.

Jim holds a BA in Biology from the University of Pennsylvania and an MBA in Global Business from Rider University.

Adam Butler Sr. Vice President, Strategic Development

Adam is responsible for strategic development for Bracket’s service offerings in Randomization and Trial Supply Management, Electronic Clinical Outcome Assessments, and Rater Training and Quality Assurance services. Adam has 12 years of experience working in the pharmaceutical services industry. Prior to his work with Bracket he worked in enterprise software development for firms including Hewlett-Packard, Bluestone Software, and Fahrenheit 450.

Stephane Deleger Vice President, Sales – eClinical

Stephane is the Executive Director, Account Management at Bracket. In his current role, he is responsible for the global sales of Bracket service offerings in Randomization and Trial Supply Management and Electronic Clinical Outcome Assessments. Stephane has been working in the healthcare industry for over 15 years, when he started his career as a biostatistician working for CROs and sponsors. Prior to joining Bracket, Stephane was an eClinical Sales Manager, and also worked as an Epidemiologist for the Public Health Institute in Berkeley, California.

Stephane holds a Master’s Degree in Cellular Biology and a Post Graduate Degree in Biomathematics from the University of Pierre et Marie Curie, Paris, France.

Jason Henson Vice President, Finance

Jason leads all finance and accounting functions for Bracket. He has more than 20 years of experience in finance and financial planning roles. Prior to Bracket, Jason was Vice President of Finance at Ricoh Americas Corporation, a global technology and document management solutions provider based in Malvern, PA. Jason received his BS in Accounting from Wake Forest University.

Kimberly A. Love Vice President of Human Resources

Kimberly A. Love, PHR, SHRM-SCP, has joined Bracket as Vice President of Human Resources and will be leading the Human Resources functions globally to attract, develop, position, and retain talented employees who will fuel and support the strategy to become a leading science technology and service leader by making a difference through people.

Kimberly is a strategic Human Resources Executive possessing a diverse history in various industries including, financial services, retail health care, consumer goods, mortgage, and supply chain. She joins Bracket from Rite Aid, having led as the Sr. Director of Human Resources of Supply Chain providing human resources leadership to distribution centers across the country and influencing more than 4800 business leaders and employees.

Kimberly holds a B.S. in Human Resources from Point Park University and an MBA from University of Phoenix.

Thomas Barlow Associate Vice President, Total Quality Management

Thomas is responsible for all of Bracket’s Quality Management Systems. Thomas has over 15 years of Quality Management experience. Prior to Bracket, he was Manager Quality Services for Clarix LLC and Quatern, LLC and the Audit Manager for Almac Clinical Technologies. Thomas holds a BS in Biology from Millersville University and has formalized training in Good Clinical Practices (GCP), Good Manufacturing Practices (GMP), 21 CFR 11, FDA, ICH and IEEE Validation Guidelines, HIPAA, CAPA Management, Deviation / Incident Reporting and Project Management.

Scientific Leadership

Bracket's Subject Matter Experts… Ahead in Every Aspect

David G. Daniel, MD Sr. Vice President and Chief Medical Officer

Clinical Professor of Psychiatry, George Washington University

Dr. Daniel provides overall scientific, clinical and strategic direction for Bracket’s services.

Dr. Daniel was the founder and President of Global Learning, LLC which was acquired by United BioSource Corporation in July 2006. He formerly served as Medical Director of the NIMH Neuroscience Center at Saint Elizabeth’s, Director of Clinical Trials for the Stanley Foundation, and was a founding Principal of Best Practice, LLC.

For over 20 years, Dr. Daniel has supervised and trained raters in psychiatric clinical trials in the US and globally. He has published numerous scientific articles involving clinical trials and investigations of the psychopathology of mental illness. He has received patent protection for new treatment approaches in epilepsy, anxiety disorders and psychotic disorders.

Dr. Daniel graduated Phi Beta Kappa and Magna Cum Laude from Emory University and obtained his medical school and psychiatry post-graduate training at Vanderbilt University, where he served as chief resident. He was a medical staff fellow and senior staff fellow within the intramural program of the National Institute of Mental Health (DIRP, NIMH) for five years.

Steve Targum, MD Scientific Director

Dr. Targum consults widely to the pharmaceutical industry regarding the design and implementation of clinical trials for new psychotropic drugs and the progression of drug development from concept to approval to launch. In addition to his work at Bracket, Dr. Targum is a Chief Medical Advisor at Prana Biotechnology Ltd. and has served as Chief Medical Officer at several small biotechnology and pharmaceutical companies.

In 1991, Dr. Targum established and operated a multi-site clinical trials program in Philadelphia. As Principal Investigator, he conducted over 200 clinical drug trials in therapeutic areas that included anxiety, depression, mania, schizophrenia, and Alzheimer’s disease.

In 2001, Dr. Targum founded PharmaStar, a rater training and medical education company focused on CNS drug development and international clinical trials. The company grew quickly and became the global leader in this niche when it was sold in October 2004 to United BioSource Corporation.

Previously, He was Professor of Psychiatry and Vice-Chairman of the Department of Mental Health Sciences at Hahnemann University School of Medicine (Philadelphia) from 1989-1995. He has published over 100 scientific articles in the areas of psychopharmacology, psychobiology, and clinical trials methodology.

Dr. Targum has a B.A. in biology from Colgate University and an M.D. from Mount Sinai School of Medicine.

Joan Busner, Ph.D. Clinical Vice President

Dr. Busner has over 30 years of experience as an academic clinical psychiatric researcher. She has served as the Principal Investigator for 49 industry-sponsored psychiatric clinical trials and Sub-Investigator for 35 additional clinical trials. She has served continuously on University Institutional Review Boards (IRBs) for the 20 years that preceded her move to Bracket.

Dr. Busner is an active contributor to the psychopharmacology literature and has authored or coauthored over 100 peer-reviewed articles and national or international scientific presentations. Prior to Bracket, Dr. Busner directed the psychiatric clinical trials units of two major medical schools. She serves as Bracket’s Expert Presenter and Scientific Lead for US and multinational studies of depressive disorders, anxiety disorders, attention deficit hyperactivity disorder and all child and adolescent psychiatric indications.

She has trained thousands of psychiatric clinical trial investigators across the globe and lectures frequently on the application of objective rating scales in the assessment of diagnosis and efficacy in psychopharmacology, ethics in psychiatric research, the placebo effect in psychiatric research and techniques for its minimization, the role of IRBs and clinical trial methodology.

Dr. Busner received her PhD in Experimental Social Psychology and her MA in General Psychology from Adelphi University. She is licensed to practice psychology in Pennsylvania, Missouri and New York.

Lewis M. Fredane, MD Clinical Vice President

As Clinical Vice President, Dr. Fredane will serve as the Therapeutic Area Leader for neurology and will oversee Bracket’s eCOA, Rater Training, and Quality Assurance work in this important therapeutic area.

Prior to joining Bracket, Dr. Fredane served as a practicing neurologist and clinical assistant professor of Neurology at Drexel University College of Medicine in Philadelphia, Pennsylvania. He has worked in pharmaceutical drug development at several companies including at Sanofi/Genzyme Pharmaceuticals, Meda Pharmaceuticals and with CRO Omnicare Clinical Research. He also maintains extensive experience in medical affairs and has published research on multiple sclerosis, pain management and transplantation.

Dr. Fredane received his medical degree from Albert Einstein College of Medicine and completed his training with a residency in Neurology at Duke University. He completed fellowships in Clinical Immunology at St. Luke’s-Roosevelt Hospital Center in New York and in Immunology at Yale University School of Medicine in New Haven, Connecticut through a research fellowship with the National MS Society.

Scott Hamilton, PhD Principal Biostatistician

Adjunct Professor, Stanford University School of Medicine, Dept. of Neurology and Neurological Sciences

Dr. Hamilton was President and Founder of DynaRand, LLC, a software company that pioneered the development of IVRS and IWRS solutions for clinical trials management. DynaRand was acquired by United BioSource Corporation in 2005. Since the inception of DynaRand in 1998, he has pioneered the use of IVRS for automated adaptive studies, especially in the area of dynamic randomization. Dr. Hamilton works closely with pharmaceutical companies regarding the statistical aspects of adaptive trials and randomization algorithms, in addition to monitoring the integrity of Bracket’s randomization processes.

Previously, Dr. Hamilton held a role of Senior Biostatistician at Genentech, Inc. and is a NI-NINDS Grant Review Committee member. Widely published, he holds memberships in the American Statistical Association and the American Academy of Neurology and Biometrics.

Dr. Hamilton received his undergraduate degree from the University of California at Davis in Economics and Rhetoric, his Master of Science from the University of California at Los Angeles in Biostatistics, and his PhD in Biostatistics from the University of North Carolina.

Amir Kalali, MD Executive Advisor for Global Strategy

Dr. Kalali helps identify innovative technologies to support the evolution of Bracket’s growth. In addition, Dr. Kalali will assist in the acceleration of growth in Bracket’s CNS product lines in other fields of medicine.  He is Professor of Psychiatry at University of California San Diego, Editor of the journal Innovations in Clinical Neuroscience, and the Lead Editor of the book Essential CNS Drug Development, published by Cambridge University Press. He has authored over 150 peer-reviewed publications.

Recognized globally as a leader in drug development and healthcare with an emphasis on  innovation, collaboration, and the intersection with new technology, Dr. Kalali was the Founding Chairman of the Executive Committee of the International Society for CNS Drug Development  (ISCDD), a founding member of the International Society for CNS Clinical Trials and  Methodology (ISCTM), where he serves on Executive Committee, the Scientific Committee, and  previously chaired the Membership and Publication Committees. He is also a founder and Co- Chair of the Scientific Program Committee of the CNS Summit, and serves on the Scientific Program Committee of the American College of Neuropsychopharmacology. Dr. Kalali regularly presents at national and international scientific meetings, and lectures  frequently on drug development, innovation, technology, digital medicine and health.  He is an advisor to the Center for Digital Transformation at the Paul Merage School of Business  at the University of California, Irvine.

Dr. Kalali earned his medical degree from the University of London and completed his psychiatry training at University College and Middlesex School of Medicine, University of London.

Alan Kott, MUDr Clinical Vice President and Practice Lead, Data Analytics

Dr. Kott is based in Bracket’s Prague office and until recently was Senior Clinical Manager for Europe. Having led the development of the Data Analytics Program for Bracket, he has overseen the design and reporting of data analytics in multiple large schizophrenia studies. For the past seven years, he has also provided training to investigators as an Expert Trainer.

Dr. Kott has been responsible for the design and implementation of multiple in-study data quality programs and served as a Product Business Owner for Rater Reliability Statistical Measures Application. Prior to Bracket, Dr. Kott worked as a house officer in Psychiatry at General Teaching Hospital, Department of Psychiatry, and as an Assistant Professor at Charles University, 1st Medical Faculty – Department of Psychiatry, in Prague. Dr. Kott has a Medicinae Universae Doctor (MUDr) from Charles University.

David S. Miller, MD, MA Clinical Vice President

Dr. Miller has over 20 years of clinical, clinical research and teaching experience, primarily in the field of geriatric psychiatry. After completing his 2-year fellowship in geriatric psychiatry at the University of Pennsylvania, he joined the faculty and served as an Assistant Professor of Psychiatry. Dr. Miller then went on to the University of Medicine and Dentistry of New Jersey, where he served as an Associate Professor of Psychiatry.

Prior to joining Bracket, Dr. Miller served as Chief of Geriatric Psychiatry, Medical Director of ECT, and President of the Medical Staff at Friends Hospital in Philadelphia, PA. At all of these institutions, he oversaw the education and training of medical students, residents and fellows in geriatric psychiatry, and was recognized with a departmental teaching award.  Dr. Miller has served as a Principal Investigator in a number of dementia clinical trials. In addition, he has lectured locally, nationally and internationally on his dementia related research.

Dr. Miller serves as the Co-Chair of the ISTAART funded Neuropsychiatric Syndromes in Dementia – Professional Interest Area (NPS-PIA), and as the Co-Chair of the ISCTM Working Group focusing on the same area. Additionally, Dr. Miller is a co-author on the updated ADCS ADAS-Cog administration and scoring manual.

Since joining Bracket, Dr. Miller has consulted on multiple dementia protocols and has served as the Expert Presenter at dozens of investigators’ meetings across the globe, including those addressing behavioral abnormalities and agitation in the context of dementia.

Gary Sachs, MD Clinical Vice President

Associate Professor of Psychiatry, Harvard Medical School

Dr. Sachs is the Therapeutic Area Leader in bipolar disease and mood disorders at Bracket. He previously co-founded Concordant Rater Systems, a specialty provider of technologies to improve CNS clinical research. Dr. Sachs is a recognized expert clinical trialist with extensive experience in rater training and the methodologies of mood and anxiety disorder research. He has been instrumental in developing technology-based solutions for randomized controlled trials that identify correlates of high placebo response, improve signal detection and reduce the risk of failed trials.

Dr. Sachs is the founder and director of the Bipolar Clinic and Research Program at Massachusetts General Hospital (MGH) and is an Associate Professor of Psychiatry at Harvard Medical School. After graduating from the University of Pennsylvania and the University of Maryland Medical School, he completed his residency at MGH. His areas of academic interest include psychopharmacology, chronobiology, bipolar mood disorder and development of pragmatic measure-based practice guidelines.

Dr. Sachs is Chair of the National Alliance on Mental Illness Scientific Advisory Board and serves on the Scientific Advisory Board of the Depression and Bipolar Support Alliance. He has authored over 200 articles, abstracts, books and book chapters.

Social Responsibility

At Bracket, we share a sense of responsibility for the social and environmental success of our communities and the human health of our employees and patients worldwide. Supporting organizations that improve the wellbeing of our planet and people is integral to our business.


Our teams take pride in supporting local organizations by organizing and participating in volunteer-led events during regular work hours.

Organization: Reading Family Aid
Event: Toys & Teens Appeal
Date: December 2017
Location: Reading, UK

The Bracket UK staff volunteer to help sort toys for needy families to help them celebrate Christmas

Organization: Alzheimer’s Association
Event: Walk to End Alzheimer’s
Date: November 2017
Location: Philadelphia, PA

More than 40 Bracket employees raised money for the Alzheimer’s Association and participated in the walk. The company team won the Rookie of the Year Award for being the highest fundraising new team in 2017.

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Organization: National Alliance on Mental Illness (NAMI) of PA Montgomery County
Event: 6th Annual Benefit for the Brain
Date: November 2017
Location: West Conshohocken, PA

Bracket sponsored this event to support both medical and non-medical research and services for mental illness. Bracket team members attended to raise funds to educate, support and advocate for those living with mental illness.

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Organization: Macmillan Cancer Support
Event: Breakfast & Coffee Fundraiser
Date: September 2017
Location:  Reading, UK

The Bracket UK staff volunteered to raise money in aid of the national World’s Biggest Coffee Morning held each year by the Macmillan Cancer Support charity.

Organization: Anti-Defamation League (ADL)
Event: Walk Against Hate
Date: May 2017
Location: Philadelphia, PA

Bracket employees participated in ADL’s 7th Annual WALK Against Hate to take part in a one-of-a-kind initiative in which people from various backgrounds are united to make strides toward embracing diversity.

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Organization: National MS Society
Event: Walk MS
Date: April 2017
Location:  Phoenixville, PA

Bracket employees participated in the MS Walk and wore orange shirts walking the trail for awareness.

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Organization: American Cancer Society
Event: Making Strides Against Breast Cancer Walk
Date: 2016 & 2017
Location:  Montgomery County, PA

For two years in a row, Bracket employees have walked to raise money for breast cancer research and to show support and solidarity for their fellow colleagues who are survivors.

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Organization: Special Olympics PA
Event: Fall Festival for Special Olympics
Date: November 2016
Location:  Villanova University

Bracket employees volunteered at the Fall Festival for Special Olympics located at Villanova University.

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Organization: MS Society
Event: Bike MS, City to Shore Ride
Date: 2011, 2012, 2013, 2014
Location:  New Jersey

Four years in a row, Bracket employees participated in the MS Society’s City to Shore Ride, a 75 mile bike ride, to raise awareness for MS.



We strive to ensure our business practices have minimal impact on the environment. We are committed to implementing green business initiatives at our offices across the globe.

Energy Conservation
We purchase only Energy-Star certified office and computer equipment and only Energy-Star certified appliances and equipment are used in new construction projects. To reduce our energy usage in existing offices, we have installed blinds, light sensors, and compact fluorescent bulbs, which use about 75% less energy than standard bulbs.

Waste Reduction
Bracket provides employees with filtered-water coolers, reusable coffee mugs, and BPA free tumblers to reduce plastic and paper waste.

Green-Friendly Facilities and Construction
Many of our office buildings are Class A, LEED, or Energy Star certified. When constructing new offices, we work with industry professionals who help to design our offices with sustainability goals in mind. Bracket uses recycled building products and paint free of or containing low amounts of volatile organic compounds.

Bracket Membership

We are proud and honored to be a part of the Global Community

Alzheimer’s Association Research Roundtable

Bio Supply Management Alliance

CDISC Clinical Data Interchange Standards Consortium

SCDM Society for Clinical Data Management

ISCTM International Society for CNS Trial Methodology

Critical Path ePRO Consortium

CNS Summit Organizing Committee